It's my experience that, all the above is accurate, in given driving conditions whether it's acceleration, or maintaining speed. But it gets back to the accelerator-pedal.
If one honestly considers their driving style, saying I want good MPGs while adding another potential 50HP in the same sentence, is often a contradiction.
Me, I enjoy the "Pull" of acceleration. I enjoy being able to safely, accelerate around a slow vehicle on a 2-lane. Knowing that, in a stock/OEM 1st gen Cummins, I'd most likely have the pedal to the floor a lot of the time. Adding bigger injectors just feeds the flame.
One can hack the IP and get good mileage, with proper working of the throttle. Or one can properly tune the AFC system, as well as the injection event timing and get more
consistent improved mileage, that's a lot more driver friendly.
If you want larger injectors, then there's a good chance you'll have them do their job. That extra power costs MPGs.
All you can do is make sure you maintain or improve the engine's efficiency.
